Downstream processing in biochemical manufacturing
In the chemical or bioprocess engineering industry, products must be separated from a complex media mixture and freed from impurities. This is an important step in guaranteeing a product with the required purity in the entire downstream processing chain.
Working together to make our customers successful
By working with the YMC Process Technologies team, we were able to develop solutions to face the challenges of pharmaceutical production and FDA requirements, all in record time. The combined expertise of Bürkert and YMC allowed us to significantly accelerate the continuous bioprocess flow in chromatography applications.
Learn more in this short video.
Chromatography operation principle
The stationary and mobile phase of liquid chromatography
The precise and safe purification of substances using chromatography is an essential step in the manufacture of fine chemicals. For this purpose, biophysical principles are applied to take advantage of the various flow properties and velocities of the components. The individual components are separated between a stationary phase (the tubular column in a column) and a mobile phase, which flows through the stationary packing (in this case a liquid).
What is the media separation process?
To purify liquids (downstream processing) out of a variety of components, a liquid needs to go through a chromatography process. Due to the various velocities at which all liquids are pumped through the system, individual components can be separated based on the different flow properties and varying interactions between the stationary and the mobile phases of the substances.
Why is chromatography so important?
Chromatography allows us to separate complex media mixtures with great precision. Even very complicated molecules like proteins can be gently separated from each other using chromatography. Under no circumstances should the media be mixed or contaminated. The right choice of valve is also an essential factor, as they control and distribute the media both into and out of the chromatography column.
The conventional solution and its weaknesses
A chromatography process is all about maximising to the greatest degree possible the amount of valuable end product. Under no circumstances is other media to cause contamination. As such, you need a system that is easy to rinse and offers an absolute minimum of dead space. Any necessary maintenance and repairs should be plannable as early as possible and interfere as little as possible with the productivity of the plant.
Intelligent valve block solutions for safe and efficient chromatography processes
Bürkert helps you make your sterile processes – in chromatography, for example – more economical and of course safer. We support you with block solutions that are individually tailored to your production, with optimised cleaning capability as well as high reliability and energy efficiency. With a decentralised automation solution you can permanently monitor the system. This helps you find and rectify errors more quickly and make your production processes more efficient.
Designed for controlling ultra-pure, sterile and aseptic media, the Type 2036 Robolux multiway diaphragm valve is the ideal solution for your chromatography processes.
How you can save on maintenance with our valve block solution
A chromatography skid contains multiple valves whose diaphragms are usually replaced once a year. Unlike conventional valve solutions with two diaphragms, the Robolux Type 2036 multiway diaphragm valve operates with only one diaphragm. The following calculation illustrates the potential time savings when replacing a conventional solution with Robolux. In this example, we assume 30 valves in the chromatography sector for a conventional solution. With Robolux you only need 15 diaphragms.
Conventional solution Robolux
How you can reduce product mixing with our valve block solution
Greater productivity thanks to smaller dead space: Three fluidic concepts result in three differently sized dead spaces. Your productivity improves if you can reduce dead spaces and thus minimise product mixing. Find out how big your savings potential can be in a concrete calculation example.
You can find more interesting information on the topic here:
Robolux multiway multiport diaphragm valve, pneumatically operated
- Allows optimized processes designs
- Reduced installation costs
- Reduced number of valves and welds
- Stainless steel bodies in different configurations
- Approvals FDA, CE, USP VI, ATEX/IECEx, 3.1
Products for fluidic solutions in the pharmaceutical sector and advice on the topic
Discover our process valve range, particularly those for strict hygiene requirements in the pharmaceutical industry.
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